About

Our team is powered by experienced, high-performing scientists who bring curiosity, creativity, and rigor to every pursuit. We thrive on collaboration—knowing that true breakthroughs happen when brilliant minds unite across disciplines.

Our Team

Markus Renschler, M.D.

Chief Executive Officer

Laure Escoubet, Ph.D.

Chief Science Officer

Christoph Zapf, Ph.D.

Vice President of Chemistry

Mark Gallop, Ph.D.

Strategic Advisor

David Gaiero

Chief Financial Officer

Ben Cravatt, Ph.D.

Professor, The Scripps Research Institute

Nathanael Gray, Ph.D.

Professor, Stanford University

Brian Liau, Ph.D.

Associate Professor, Harvard University

Thomas Daniel, M.D.

Chairman of the Board

Cristina Ghenoiu, Ph.D.

Mubadala Capital

Rami Hannoush, Ph.D.

Versant Ventures

Seiji Miyahara, Ph.D.

Taiho Ventures

Markus Renschler, M.D.

Chief Executive Officer

Thomas Woiwode, Ph.D.

Versant Ventures

Trusted by Leading Investors

We are proud to be funded by Versant Ventures, Mubadala Capital, and three strategic co-investors, Bristol Myers Squibb, Taiho Ventures, and AbbVie, underscoring our commitment to transforming drug discovery and advancing healthcare.

Our Values

We are guided by innovation, collaboration, scientific integrity, transparency, a sense of urgency, trust and mutual respect, and data-driven decision making. Patients can’t wait.

Careers

We are searching for creative individuals driven by a willingness to embrace innovation in a fast-paced, high-energy environment and an eagerness to challenge and meet aggressive timelines. We are looking for professionals with a strong work ethic and a commitment to teamwork, who are committed to continuous learning and will seek opportunities to stretch their capabilities. We are a passionate, results-oriented organization. We offer competitive salaries and comprehensive benefits.

Open Positions

Here are positions currently open at Light Horse Therapeutics. We do not accept unsolicited resumes from recruiters and will not pay a fee for any unsolicited resumes. For more information, contact careers@lighthorsetx.com

Head of Computational Biology

San Diego, CA
Full-time

We are seeking a highly motivated, innovative, and experienced leader to head our Computational Biology function. Reporting to the Chief Scientific Officer, this individual will play a central role in advancing Light Horse’s mission by shaping and executing the computational strategy supporting the discovery and development of first-in-class small molecule therapeutics.

Details

Job Description:

Collaborate closely with Biology, Chemistry and Proteomics, to drive data analysis and become an active participant of drug discovery and translational research from target discovery to development.
The candidate will be supported by and provide leadership to a team comprising in-house expertise and specialized external partners.
Lead the design and analysis of CRISPR-based functional gene editing screens and multi-omics datasets such as DNA sequencing, Transcriptomics and Epigenomics
Lead the analysis of genomic/genetic data for biomarker discovery
Develop methods to interrogate large OMICs data sets to support target discovery and translational research
Build and maintain computational pipelines for the integrative analysis and visualization of Genomics and Proteomics data
Oversee data infrastructure and computational environment to ensure robust data management
Stay current with scientific literature on targets/diseases of interest and emerging computational methodologies, fostering innovation across the company
Communicate data analysis and scientific strategy effectively to internal stakeholders and external partners.
Foster Light Horse’s culture of scientific excellence
Perform other duties and projects as needed in a fast-paced, dynamic environment

Required Qualifications:

PhD in Computer Science or Bioinformatics with 10+ years of Industry experience and strong publication record
Experience in Oncology and knowledge of cancer biology with experience in leveraging computational biology to support drug discovery and development
Demonstrated expertise in the design and analysis of CRISPR and NGS data
Familiar with tools and strategies for multi-omics integration.
Experience in implementing, maintaining and running data analysis pipelines using HPC or cloud-based workflows.
Strong publication record and history of presenting scientific work at conferences or in strategic meetings
Proven record of fostering productive research collaborations and working cooperatively in a matrix environment
The individual should be scientifically creative and driven by a willingness to embrace innovation in a fast-paced high energy environment and an eagerness to challenge and meet aggressive timelines

Preferred qualifications:

Experience developing interactive data visualization and dashboards
Experience working in collaboration with structural biology and computational chemistry
Familiarity with machine learning and AI applications

To apply for this position, click the link below to email our hiring team. Please include your resume and references.

Director/Associate Director Proteomics Platform

San Diego, CA
Full-time

We are seeking a visionary and accomplished Scientific Leader to spearhead our Proteomics platform. This is a high-impact leadership role within our growing organization, where you will lead an in-house expert team of chemoproteomics scientists and work collaboratively across disciplines to propel our discovery pipeline

Details

Job Description:

You will oversee all mass spectrometry and chemoproteomics activities which will impact our drug discovery portfolio of oncology programs, our early discovery pipeline intersecting with our gene editing expertise and contribute to our external collaborations. Your expertise will directly drive the validation and enablement of novel protein targets and accelerate the design of small molecules with transformative potential. Your insights will integrate into the portfolio decision-making process, and you will participate in all stages of drug discovery—from target site identification to candidate nomination.

Key Responsibilities:

Strategic Leadership

Embedded in the Chemistry group, build strong partnerships with Medicinal Chemistry, Computational Chemistry and Structural Biology to enable portfolio-facing data generation.
Collaborate closely with Discovery Biology and Target Validation teams to ensure the coordination of all proteomics activities supporting the Light Horse early target discovery and advanced discovery pipeline.
Guide scientists to enable effective design of experiments, execution of automation, optimize existing sample preparation, data acquisition methods, and data interpretation.
Define and execute the long-term proteomics strategy in alignment with company goals and research priorities. Anticipate emerging technologies, trends, and applications in proteomics, positioning the organization at the forefront of innovation.

Operational Oversight

Hands-on experience with state-of-the-art proteomic techniques.
Overseeing the all proteomics workflows from sample preparation, MS experiments to data analysis and data integration.
Responsible for maintaining Mass Spectrometry infrastructure. Ability to diagnose mass spec instrument failures and communicate with external contract team to enable effective hardware repair.
Experience in database search algorithms for proteomics (Proteome Discoverer, MaxQuant, MS Fragger, Spectronaut, DIA-NN, and Skyline).

Innovation & Culture

Contribute to the broader scientific strategy of Light Horse, fostering a culture of innovation, scientific excellence, and teamwork in a fast-paced startup environment.
Champion a culture of scientific curiosity and cross-disciplinary learning.

Qualifications

Ph.D. in Biochemistry, Analytical Chemistry, Molecular Biology, or related field with 7+ years of postgraduate experience in MS-based proteomics experience in the biopharmaceutical industry.
Proven scientific leadership with a track record of successfully impacting a biopharmaceutical research portfolio from early project inception to delivery of a clinical asset.
Ability to effectively manage scientific staff across various levels of experience.
Proven record of a strong background in chemical biology and flavors of MS-based quantitative proteomics.
Strong publication/patent record.
Strong business ethics and an active contributor to a supportive work culture.
Excellent communication and organizational skills, with the ability to manage multiple projects in parallel.
Collaborative and proactive mindset, aligned with Light Horse’s core values of integrity, excellence, and teamwork.

Why Join Us?

At Light Horse, you’ll have the opportunity to:

Work with world-class founders and scientists on some of the most challenging and rewarding problems in drug discovery.
Shape the trajectory of a rapidly growing biotech at the forefront of chemical biology and precision therapeutics.
Be a core contributor in a mission-driven team passionate about developing life-saving medicines.

We offer a competitive total compensation package, as well as working in a supportive team environment.

The anticipated salary range for candidates who will work in San Diego, CA is $178,000 to $234,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc.